Renewal on a continuous basis: Your Liver Is Only Around Three Years Old

Date:11 June 2022 Author: Juandre

An international team of scientists has discovered that the human liver remains youthful throughout life, typically less than three years old, using retrospective radiocarbon birth dating.

The liver, as one of the body’s primary organs, performs a variety of vital biological processes. Almost all of a person’s blood flows through the liver, which filters waste products, worn-out cells, and toxins. It also produces bile, a fluid that aids in the digestion of fats and the elimination of waste materials. These are only a few of the primary jobs it conducts; the liver is responsible for over 500 important functions.

The liver is a vital organ that assists in the detoxification of our bodies. Because it is continually exposed to hazardous substances, it is prone to injury. To combat this, the liver is one of the few organs that can regenerate after being damaged. Because the body’s ability to heal and regenerate itself reduces as we age, scientists wondered if the liver’s ability to renew itself did as well.

The Liver in Humans Is Still a Young Organ

Dr. Bergmann headed an interdisciplinary team of biologists, physicists, mathematicians, and doctors who examined the livers of various people who died between the ages of 20 and 84. Surprisingly, the researchers discovered that all of the participants’ liver cells were almost the same age.

“Your liver stays on average just under three years old whether you’re 20 or 84,” Dr. Bergmann adds. The findings reveal that the ongoing replacement of liver cells regulates the adjustment of liver mass to the needs of the body, and that this process is maintained even in elderly persons. This continuous liver cell replacement is critical for liver regeneration and cancer growth in many ways.

Liver cells with more DNA have a lower rate of regeneration

Not all of the cells in our liver, however, are so young. A small percentage of cells can live for up to ten years before needing to be replaced. This subset of liver cells has more DNA than the rest of the cells. “Most of our cells contain two sets of chromosomes, but as we become older, some cells gain extra DNA.” “At the end of the day, such cells can have four, eight, or even more sets of chromosomes,” Dr. Bergmann continues.

“We discovered key variations in the regeneration of ordinary liver cells and cells richer in DNA.” “Traditional cells regenerate once a year, whereas DNA-rich cells can stay in the liver for up to a decade,” adds Dr. Bergmann. “This could be a protective mechanism that protects us from collecting dangerous mutations as this fraction gradually increases with age.” We need to see if chronic liver illness, which can lead to cancer in some situations, has comparable processes.”

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